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Particle therapy for cancers: a new weapon in radiation therapy

Guo-Liang Jiang

Frontiers of Medicine 2012, Volume 6, Issue 2,   Pages 165-172 doi: 10.1007/s11684-012-0196-4

Abstract: and intensity-modulated radiation therapy, proton therapy has yielded more promising outcomes in localCarbon therapy in Japan showed even more promising results than proton therapy.The non-invasive nature of particle therapy affords more patients with chances to receive and benefitParticle therapy is gradually getting attention from the oncology community.However, the cost of particle therapy facilities has limited the worldwide use of this technology.

Keywords： radiation therapy     particle therapy     proton     carbon     cancer    

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How to judge the association of postmenopausal hormone therapy and the risk of breast cancer

Ling XU

Frontiers of Medicine 2010, Volume 4, Issue 3,   Pages 290-293 doi: 10.1007/s11684-010-0093-7

Abstract: The relevance of postmenopausal hormone therapy (HT) for breast cancer risk has been long debated, althoughThese unanswered questions include: whether HT has a positive impact on breast cancer; whether risks of therapy

Keywords： breast cancer     postmenopausal hormone therapy     unopposed estrogen therapy     combined estrogen-progestin therapy    

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Catalyst particle shapes and pore structure engineering for hydrodesulfurization and hydrodenitrogenation

Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 6,   Pages 897-908 doi: 10.1007/s11705-021-2127-x

Abstract: Catalyst particle shapes and pore structure engineering are crucial for alleviating internal diffusionThe effects of catalyst particle shapes (sphere, cylinder, trilobe, and tetralobe) and pore structuresThe relationship between particle shape and effectiveness factor is first established, and the specificThe catalyst particle shapes primarily alter the average HDS/HDN reaction rate to adjust the HDS/HDNimproving HDS/HDN catalyst particle efficiency.

Keywords： hydrodesulfurization     hydrodenitrogenation     particle shape     pore structure    

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A novel light fluctuation spectrum method for in-line particle sizing

Shouxuan QIN, Xiaoshu CAI, Li MA

Frontiers in Energy 2012, Volume 6, Issue 1,   Pages 89-97 doi: 10.1007/s11708-012-0176-z

Abstract: This paper discusses two problems in in-line particle sizing when using light fluctuation method.First, by retrieving the ratio of particle concentrations at different time, the intensity of incidentmulti-sub-size zone model is proposed, with which the relationship between the distribution of turbidity and the particle

Keywords： in-line measurement     particle size distribution (PSD)     incident light intensity     particle concentration    

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Passive antibody therapy in emerging infectious diseases

Frontiers of Medicine doi: 10.1007/s11684-023-1021-y

Abstract: In addition, the prospects of applying antibody therapy against VOCs was assessed, offering insights

Keywords： SARS-CoV-2     COVID-19     convalescent plasma     hyperimmunoglobulin     neutralizing monoclonal antibodies    

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Independent cover meshless particle method for complex geotechnical engineering

Jianqiu WU, Yongchang CAI

Frontiers of Structural and Civil Engineering 2018, Volume 12, Issue 4,   Pages 515-526 doi: 10.1007/s11709-017-0428-4

Abstract: A new Independent Cover Meshless Particle (ICMP) method is proposed for the analysis of complex geotechnical

Keywords： meshless method     particle method     independent cover     CTM     geotechnical engineering    

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Microdamage study of granite under thermomechanical coupling based on the particle flow code

Frontiers of Structural and Civil Engineering   Pages 1413-1427 doi: 10.1007/s11709-023-0953-2

Abstract: an improved temperature-dependent linear parallel bond model is introduced under the framework of a particle

Keywords： thermomechanical coupling effect     granite     improved linear parallel bond model     thermal property     particle    

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mTOR-targeted cancer therapy: great target but disappointing clinical outcomes, why?

Shi-Yong Sun

Frontiers of Medicine 2021, Volume 15, Issue 2,   Pages 221-231 doi: 10.1007/s11684-020-0812-7

Abstract: rationale, the intriguing question is why cancers are insensitive or not responsive to mTOR-targeted cancer therapyERK, and Mnk/eIF4E survival signaling pathways that compromise the efficacy of rapalog-based cancer therapyThese new findings may also offer us the opportunity to rationally utilize mTOR inhibitors in cancer therapy

Keywords： mTOR     cancer therapy     resistance     GSK3     protein degradation     E3 ubiquitin ligase     PD-L1    

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Targeted therapy of desmoid-type fibromatosis: mechanism, current situation, and future prospects

Zhen Wang, Jianhui Wu, Xiuyun Tian, Chunyi Hao

Frontiers of Medicine 2019, Volume 13, Issue 4,   Pages 427-437 doi: 10.1007/s11684-018-0672-6

Abstract: Tyrosine kinase and γ-secretase inhibitors are primarily used in the targeted therapy of DF.Previous studies that focused on the mechanism, efficacy, and safety of targeted therapy for DF wereThe efficacy and safety of targeted therapy were compared with those of other systemic therapy optionsTargeted therapy does not provide considerable advantages in efficacy and safety over other medical treatmentsstudies are required to explore the mechanism, indications, and appropriate drug dosage of the targeted therapy

Keywords： targeted therapy     desmoid-type fibromatosis     tyrosine kinase inhibitor     γ-secretase inhibitor    

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Study on direct measurement method of vorticity from particle images

RUAN Xiaodong, FU Xin, YANG Huayong

Frontiers in Energy 2007, Volume 1, Issue 4,   Pages 408-412 doi: 10.1007/s11708-007-0059-1

Abstract: vorticity measurement, a new direct measurement of vorticity (DMV) method extracting vorticity from particle

Keywords： conventional     vorticity measurement     particle     DMV     theory    

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Response surface regression analysis on FeCrBSi particle in-flight properties by plasma spray

Runbo MA,Lihong DONG,Haidou WANG,Shuying CHEN,Zhiguo XING

Frontiers of Mechanical Engineering 2016, Volume 11, Issue 3,   Pages 250-257 doi: 10.1007/s11465-016-0401-2

Abstract: response surface methodology show that the interactive effects between voltage and spray distance on particleFor a given argon flow rate, particle velocity and temperature response surface are obviously bendingWith an increase in spray distance, the interactive effects between voltage and argon flow rate on particleWith an increase in voltage, the interactive effects between spray distance and argon flow rate on particle

Keywords： particle velocity     particle temperature     interactive effects     response surface    

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Hydroxyl radical-involved cancer therapy via Fenton reactions

Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 3,   Pages 345-363 doi: 10.1007/s11705-021-2077-3

Abstract: Furthermore, the challenges and future developments of hydroxyl radical-involved cancer therapy are discussed

Keywords： hydroxyl radical     Fenton catalyst     hydrogen peroxide     cancer therapy    

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Progress in systemic therapy for triple-negative breast cancer

Hongnan Mo, Binghe Xu

Frontiers of Medicine 2021, Volume 15, Issue 1,   Pages 1-10 doi: 10.1007/s11684-020-0741-5

Abstract: Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer with a heterogeneous genetic profile. Chemotherapy exhibits substantial activity in a small subset of these patients. Drug resistance is inevitable. Major progress has been made in the genetic analysis of TNBC to identify novel targets and increase the precision of therapeutic intervention. Such progress has translated into major advances in treatment strategies, including modified chemotherapy approaches, immune checkpoint inhibitors, and targeted therapeutic drugs. All of these strategies have been evaluated in clinical trials. Nevertheless, patient selection remains a considerable challenge in clinical practice.

Keywords： triple-negative breast cancer     immunotherapy     targeted therapy    

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Analysis of molten metal spreading and solidification behaviors utilizing moving particle full-implicit

Frontiers in Energy 2021, Volume 15, Issue 4,   Pages 959-973 doi: 10.1007/s11708-021-0753-0

Abstract: In the numerical analysis, the moving particle full-implicit method (MPFI), which is one of the particle

Keywords： molten metal spreading     solidification     particle method     severe accident     fuel debris     decommissioning    

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Translational medicine promising personalized therapy in oncology

Yi-Xin ZENG, Xiao-Shi ZHANG, Qiang LIU,

Frontiers of Medicine 2010, Volume 4, Issue 4,   Pages 351-355 doi: 10.1007/s11684-010-0320-2

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Title Author Date Type Operation

Particle therapy for cancers: a new weapon in radiation therapy

Guo-Liang Jiang

Journal Article

How to judge the association of postmenopausal hormone therapy and the risk of breast cancer

Ling XU

Journal Article

Catalyst particle shapes and pore structure engineering for hydrodesulfurization and hydrodenitrogenation

Journal Article

A novel light fluctuation spectrum method for in-line particle sizing

Shouxuan QIN, Xiaoshu CAI, Li MA

Journal Article

Passive antibody therapy in emerging infectious diseases

Journal Article

Independent cover meshless particle method for complex geotechnical engineering

Jianqiu WU, Yongchang CAI

Journal Article

Microdamage study of granite under thermomechanical coupling based on the particle flow code

Journal Article

mTOR-targeted cancer therapy: great target but disappointing clinical outcomes, why?

Shi-Yong Sun

Journal Article

Targeted therapy of desmoid-type fibromatosis: mechanism, current situation, and future prospects

Zhen Wang, Jianhui Wu, Xiuyun Tian, Chunyi Hao

Journal Article

Study on direct measurement method of vorticity from particle images

RUAN Xiaodong, FU Xin, YANG Huayong

Journal Article

Response surface regression analysis on FeCrBSi particle in-flight properties by plasma spray

Runbo MA,Lihong DONG,Haidou WANG,Shuying CHEN,Zhiguo XING

Journal Article

Hydroxyl radical-involved cancer therapy via Fenton reactions

Journal Article

Progress in systemic therapy for triple-negative breast cancer

Hongnan Mo, Binghe Xu

Journal Article

Analysis of molten metal spreading and solidification behaviors utilizing moving particle full-implicit

Journal Article

Translational medicine promising personalized therapy in oncology

Yi-Xin ZENG, Xiao-Shi ZHANG, Qiang LIU,

Journal Article